The resignations, along with the recent departure of former superintendent Arlene Ackerman, means that Philadelphia will be facing new leaders at the helm.
The district and the Tacoma Education Association have been negotiating without success since May 31.
Striking teachers say they're looking for a fair teacher reassignment policy and smaller class sizes.
Middle-class schools educate the most students, but have surprisingly low achievement results, according to Third Way, a think-tank advocating moderate policy ideas.
The anonymous donors who pledged to support the deal withdrew in the face of suspicion over the deal.
School leader groups note that private-sector executives earn far more.
A school administrator caught up in the Atlanta cheating investigation was asked to resign after only one day in a new job.
Paul Vallas argues that his successor, Arlene Ackerman, took over a smoothly-running district when she started in 2008.
John Covington, who served in the 17,400-student district for two years, will oversee a system of underperforming schools throughout the state.
John Covington, the schools leader in Kansas City, said Wednesday he planned to leave the district in 30 days; James Williams, the superintendent in Buffalo, has also made plans to leave.