"We are sending a signal that we are unhappy with these regs," said Tyler Hernandez, a spokesman for the House education committee.
Without another Republican senator joining the two who say they'll vote against the education secretary nominee, the tally appears to be 50-50, assuming all Democrats vote "no."
It's unclear whether President Donald Trump's $20 billion federal voucher plan has legs. But don't mistake that for a lack of overall enthusiasm among GOP lawmakers for expanding school choice.
The recommendations include ideas like collecting better data on student outcomes, improving access to early childhood education, and beefing-up teacher quality.
"She clearly said to me that the states need to be in control of a lot of these decisions," said Chris Minnich, the executive director of the Council of Chief State School Officers.
Sen. Susan Collins, R-Maine, and Sen. Lisa Murkowski, R-Alaska, said they would vote against DeVos over concerns about her track record with and knowledge of public schools.
A 2015 Senate vote on a federal school choice bill provides a clue about which senators might not be big DeVos fans.
The short answer: Maybe not quite as much as you might think. For one thing, the Every Student Succeeds Act doesn't give her much running room.
Democrats tried a variety of tactics to attack DeVos' nomination, questioning her fitness for the job, her political background, and her ability to avoid conflicts of interest.
The Senate education committee is meeting Tuesday to vote on President Donald Trump's nominee for education secretary, Betsy DeVos, a billionaire school choice advocate, best known for her work chairing the American Federation for Children.