The Jan. 30 letter from the Leadership Conference on Civil and Human Rights was released one day before the Senate education committee's scheduled vote on DeVos' nomination.
The issue of the regulatory burden coming from the federal government has come up recently in connection with higher education and with a spending requirement in the Every Student Succeeds Act.
Teachers, former education secretaries, and others with links to education are speaking out about President Donald Trump's executive order about refugees and international travel.
Moderate senators appear likely to support DeVos, meaning she will almost certainly be confirmed. But Democrats are already fundraising off of the controversy surrounding her nomination.
School choice is front-and-center in national debates about education, in large part because of Trump's nominee for education secretary, Betsy DeVos.
Jason Botel's move might surprise some of those who view Trump's education policy through a strictly partisan or conservative lens.
EdWeek reached a handful of Republican teachers and others who voted for President Donald Trump, but oppose Betsy DeVos, his pick for education secretary.
"I believe that all students, including individuals with disabilities, deserve an equal opportunity to lead full, productive and successful lives," DeVos wrote in her Jan. 24 letter to Sen. Johnny Isakson, R-Ga.
President Donald Trump's executive order affecting many federal agencies, with the exception of military employees, could mean longer hours for career staff and slower response to inquiries.
The nominee for education secretary would still need to build bridges in Congress and overcome the skepticism of many in the education community.